Stability of Imipenem and Cilastatin Sodium in Total Parenteral Nutrient Solution
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چکیده
منابع مشابه
Pharmacokinetics of imipenem-cilastatin in neonates.
Imipenem and its renal dehydropeptidase I inhibitor, cilastatin, were coadministered intravenously in a 1:1 ratio to 30 newborns. Five infants each received single doses of 10, 15, or 20 mg/kg of both drugs. Concentrations in plasma were proportional to the administered dose, and cilastatin achieved consistently higher concentrations than did equivalent doses of imipenem because of its smaller ...
متن کاملImipenem/cilastatin: rationale for a fixed combination.
Imipenem is renally metabolized to the stable open-lactam metabolite by a dipeptidase, dehydropeptidase I, located at the lumenal surface of the proximal tubular cells. In humans the degree of hydrolysis shows marked intersubject variability but minimal intrasubject variability. In healthy subjects the urinary recovery of unchanged imipenem ranged from 5.5% to 42.5% of the dose. Cilastatin inhi...
متن کاملImipenem-cilastatin-induced psychosis: a case report.
BACKGROUND Elderly patients, in particular, have been reported to develop psychiatric side effects from antibiotics. Clarithromycin, quinolones, sulfamethoxazole-trimethoprim, isoniazid, penicillin, and cephalosporins have been reported to cause psychosis. This case report bridges a void in the medical literature with regards to the psychiatric adverse effects of imipenem-cilastatin. CASE PRE...
متن کاملimipenem/cilastatin prescription and dosing in a tertiary care hospital
License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be f...
متن کاملModification of acquired immunity in mice by imipenem/cilastatin.
The immunomodulating properties of antimicrobial drugs may have important implications for clinical practice, particularly for those patients whose immune system has been compromised. In this study, we assessed the influence of different treatments with a beta-lactam antibiotic (imipenem/cilastatin) on several acquired immune responses of BALB/c mice; splenocyte responses to specific mitogens a...
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ژورنال
عنوان ژورنال: Journal of Parenteral and Enteral Nutrition
سال: 1990
ISSN: 0148-6071,1941-2444
DOI: 10.1177/0148607190014003306